Ingredient · Signal Peptide
Palmitoyl Tetrapeptide-7
INCI · Palmitoyl Tetrapeptide-7
Palmitoyl tetrapeptide-7 (INCI: Palmitoyl Tetrapeptide-7; Pal-GQPR) is a small signal peptide attached to a palmitic acid tail, frequently presented with palmitoyl pentapeptide-4. This pair forms the two peptides in the INCI listing of a well-known commercial peptide complex, for example in "Matrixyl 3000" messaging. The key to reading this page is to read both peptides on the label independently of the brand name, because the INCI list shows the peptides themselves, not the brand. Palmitoyl tetrapeptide-7 has been studied for the appearance of skin surface balance and comfort and, in some sources, for matrix and inflammatory-response signals. Restraint is needed: being a signal peptide is not the same as producing a noticeable topical result, because effects depend on penetration, concentration and formulation. It is used at very low concentrations, generally ppm levels. Labels show "Palmitoyl Tetrapeptide-7", and its PubChem record was verified by CAS (CID 10078408, C34H62N8O7; confirmed with CAS 221227-05-0). The main peptide page covers the general class; this page focuses on palmitoyl tetrapeptide-7's structure and combination context. When assessing a palmitoyl tetrapeptide-7 product, Klaris reads accompanying peptides, concentration and the whole formula together.
i. Cosmetic Functions
Frequently Discussed Effects
The following headings summarise areas of effect frequently discussed in the literature; visible results in each area require regular use and a suitable formula.
A Signal Peptide
It is studied in the literature for the appearance of balance and comfort at the skin surface.
A Two-Peptide Combination
It is formulated with pentapeptide-4 as a common peptide pair.
Low Concentrations
It is a lightweight ingredient used at very low concentrations.
Mechanism
What Happens Within the Skin?
The following points summarise mechanisms from dermocosmetic literature in plain English. Klaris presents them as background information to help readers understand the context, not as medical claims.
Step 1
A Matrikine Signal Peptide
It is a small signal peptide attached to a palmitic acid tail (Pal-GQPR), studied in the context of skin matrix and surface-appearance signals.
Step 2
A Pair with Pentapeptide-4
It is often presented with palmitoyl pentapeptide-4 as one of the two peptides in the INCI listing of a well-known commercial complex.
Step 3
INCI, Not the Brand
A product's INCI list shows these peptides rather than the brand name; reading both together reveals the actual ingredients.
Step 4
Very Low Concentrations
It is a lightweight ingredient used at very low concentrations, generally ppm levels.
Step 5
A Measured Reading of Effects
Being a signal peptide is not the same as delivering a topical result; effects need measured interpretation according to penetration, concentration and formulation.
ii. Role in the Formula
How Is It Read on a Label?
Palmitoyl tetrapeptide-7 is one of two peptides in the INCI listing of a well-known commercial peptide complex, the other being pentapeptide-4. Reading these two together, independently of the brand name, helps reveal the actual formula contents. It appears at low concentrations in serums and creams.
A Closer Look · pH, Stability, Synergy
Palmitoyl tetrapeptide-7 rarely appears alone in formulation. It mostly joins palmitoyl pentapeptide-4 as one of two peptides in the INCI listing of a well-known commercial complex, often discussed as "Matrixyl 3000". For Klaris, the most practical reading framework is the trade-name/INCI distinction: the label shows "Palmitoyl Tetrapeptide-7" and "Palmitoyl Pentapeptide-4", not the brand name. Reading this pair helps reveal the actual ingredients behind the brand narrative. Palmitoyl tetrapeptide-7 has been researched in the context of matrix signals and inflammatory responses, but that research must not directly become a cosmetic promise to "produce collagen" or "eliminate wrinkles". It is used at very low concentrations, generally ppm levels, and effect size requires measured interpretation according to penetration, which may be limited or debated across the skin barrier, concentration and formulation. A complex name or brand story alone signals neither quality nor results. The main peptide page covers general distinctions between signal, carrier and enzyme-inhibitor peptides; this page focuses on palmitoyl tetrapeptide-7, its structure, the two-peptide combination and concentration. When assessing a palmitoyl tetrapeptide-7 product, Klaris reads accompanying peptides, concentration, consistency between brand messaging and the actual INCI list, and the whole formula together.
Typical Concentration Range
Very low concentration (on a complex basis, often ppm levels)
Ingredient Family
Renewal Ingredients
iii. Sensitivity Advisory
A Note on Extra Care in Context
Peptides are generally described as having low-irritation profiles; a patch test is a measured approach for sensitive profiles.
A sensitivity advisory is not an instruction for use; where individual health circumstances, pregnancy or known sensitivities are involved, discussing the decision with your doctor may be a more contextual approach.
Common Misconceptions
Frequently Confused Points
Common Belief
Palmitoyl tetrapeptide-7 produces collagen and eliminates wrinkles.
A More Contextual Reading
It has been researched in matrix and signal-peptide contexts, but being a signal peptide does not directly become a cosmetic promise to "produce collagen or eliminate wrinkles". Effects require measured interpretation according to penetration, concentration and the whole formula.
Common Belief
"Matrixyl 3000" is a special active, different from the INCI list.
A More Contextual Reading
The INCI counterpart of the brand narrative is the palmitoyl tetrapeptide-7 and palmitoyl pentapeptide-4 pair shown on the label. The brand name alone is not a quality signal.
Common Belief
Two peptides together guarantee an effect.
A More Contextual Reading
A two-peptide combination is a common formulation approach, but results come from the whole formula and regular use, not one combination. "Contains the pair" alone is no guarantee.
Common Belief
As a peptide, it must penetrate skin and have an effect.
A More Contextual Reading
Peptide passage across the skin barrier may be limited or debated. Although the palmitoyl tail supports compatibility, topical effect size is not guaranteed and needs context.
Scientific Basis
Sources and Their Scope
The following headings indicate areas of research; they are not citations of a specific publication or confirmation that every statement on this page has been verified. The links provided should be read with their individual scope in mind.
- International INCI / CosIng Database
- Dermocosmetic Research Publications
Source Links
Database records provide ingredient identity and registration information; on their own, they do not establish the effect of a finished product or its suitability for a profile. Search links are not specific research papers.
iv. Related Ingredients
Ingredients Often Read Together
v. Renewal Ingredients Family
Other Ingredients in the Same Family
Explore ingredients in the same functional family to deepen your reading of formulas.
vi. Academy · Related Reading
For a Closer Look
Klaris · Example Analyses
How Does Palmitoyl Tetrapeptide-7 Feature
in Your Products?
Explore product examples to see the ingredient list, general assessment and match score that changes with the example profile together.
Masked products and example profiles, not a personal analysis. Profile matching in the app is part of Klaris Premium. The app is currently available in Turkish. An English version is in preparation.